A new approach to lymphedema following breast cancer treatment with lymphatic endothelial cell markers
نویسندگان
چکیده
Amaç: Lenfödem (LE), aksiller lenf nodu diseksiyonu ve radyoterapi ile tedavi edilen meme kanserli olgularda yaygın gelişen iyatrojenik bir komplikasyondur. Bu çalışmada lenfödemli hastalarda kanseri tedavisi sonrası, lenfatik sistem endotelinden salınan, homeobox transkripsiyon faktörü (Prox-1), damar endotel reseptörü-1 (LVYE-1) podoplanin (PDPN) belirteçlerinin serum düzeylerini araştırmayı amaçladık.
 Metod: Çalışmanın LE grubunu sonrası üst ekstremitede toplam 44 kadın hasta, kontrol ise demografik açıdan grubu benzer özellikler gösteren sağlıklı oluşturdu. Hastaların kol çevreleri ölçüldü her iki çevresi toplamları arasındaki fark (DSOAC) 2 cm veya ≥ %10 olarak kabul edildi. Serum Prox-1, LVYE-1 PDPN konsantrasyonları ticari ELISA (Enzyme-linked immunosorbent assay) ölçüldü.
 Bulgular: grubunda seviyeleri grubuna göre anlamlı düşük bulundu (sırasıyla; p < 0.01, = 0.02, 0.04). Prox-1 Evre 1 LE'li LE’li hastalara yüksekti (p
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ژورنال
عنوان ژورنال: Journal of health sciences and medicine
سال: 2021
ISSN: ['2636-8579']
DOI: https://doi.org/10.32322/jhsm.902393